Syntheses of vitamin D analogues. I.
نویسندگان
چکیده
منابع مشابه
New vitamin D analogues.
This article is a short review of recent advances in structure-activity relationships and in design and synthesis of vitamin D analogues having various desirable biological activities, with emphasis on work in the author's laboratory.
متن کاملTherapeutic applications of vitamin D analogues.
In the sunnier parts of the world a dietary intake of vitamin D is unnecessary,* but for most of us it is a true vitamin. Its dihydroxylated metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2DO) is, however, a hormone synthesised in the kidney and borne by the bloodstream to distant target organs (gut, bone, and possibly the parathyroid glands) with a complex feedback mechanism regulating its rate ...
متن کاملVitamin D analogues for secondary hyperparathyroidism.
Secondary hyperparathyroidism (2HPT), a common disorder in patients with chronic renal failure, develops in response to phosphate retention and low serum 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), calcitriol). Replacement therapy with calcitriol or its precursor 1alpha-hydroxyvitamin D(3) (1alphaOHD(3), alfacalcidol) often produces hypercalcaemia, especially when combined with calcium-based p...
متن کاملConvergent syntheses of LeX analogues
The synthesis of three Le(x) derivatives from one common protected trisaccharide is reported. These analogues will be used respectively for competitive binding experiments, conjugation to carrier proteins and immobilization on gold. An N-acetylglucosamine monosaccharide acceptor was first glycosylated at O-4 with a galactosyl imidate. This coupling was performed at 40° C under excess of BF₃.OEt...
متن کاملAN APPROACH TO THE A RING OF VITAMIN D ANALOGUES VIA SEQUENTIAL CARBOMETALATION/ ANION CAPTURE
An intramolecular palladium catalysed carbometalation followed by anion capture achieves construction of a model comprised of the A ring of Vitamin D oxygen analogues.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1982
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.30.4593